For example, tumor cell-derived microparticles containing the chemotherapeutic drug methotrexate (TMP-MTX), nanoparticles delivering shikonin and PD-L1 knockdown siRNA (SK/siR-NPs), and Gadofullerene (GF-Ala) nanoparticles can all reprogram M2 TAMs to an M1-like phenotype and increase the infiltration of CTLs, thereby effectively inhibiting tumor growth (100–102). Here, CD274 is linked to neoplasm.