TP53 exon 8 G/C-to-A/T mutations were more frequent in R/R DLBCL samples (83.33%, 15/18) than in non-R/R DLBCL (23.26%, 10/43) samples (χ2 = 18.93, p < 0.001) (Figure 2C). Here, TP53 is linked to diffuse large B-cell lymphoma.