Based on the circulating transcriptome datasets of GSE11947 (for WGCNA) and GSE59867 (for validation), upregulated protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A), syndecan-binding protein (SDCBP), EVH1-domain-containing protein 2 (SPRED2), and vesicle-associated membrane protein-3 (VAMP3) were proved to be highly correlated with HF progression after AMI. The gene discussed is SDCBP; the disease is hydrops fetalis.