CD40LG and endometriosis: Many studies suggest that women with endometriosis may have a hormonal imbalance and be prone to other immune surveillance-related imbalances such as suppressed cell-mediated immunity (high T, B, and NK cell counts, but lessened activity) and increased antibody-mediated immune response (high serum levels of immunoglobulin IgA, IgG, IgM, and anti-endometrial antibodies) (30).