IL4 and ascariasis: Human studies looking at gene ontology pathway analysis in children with active S. hematobium and Ascaris lumbricoides infections identified inhibition of IFN-γ signaling, cellular proliferation and the Th1 pathway by DNA hypermethylation of the Th1 pathway and hypomethylation of IL-4 pathway leading to increased IL-4 production by CD4+ T cells (255).