We previously demonstrated that the decrease in BDNF triggers self‐aggregated Aβ‐induced neurite fragmentation as well as two types of neuronal cell death, namely caspase‐6‐dependent apoptosis and necroptosis, in an AD mimic cell model using neuron‐like differentiated SH‐SY5Y (ndSH‐SY5Y) human neuroblastoma cells (Tagai et al., 2020). Here, CASP6 is linked to Alzheimer disease.