We compared the expression of OAS3 in normal and tumour tissues of 33 cancers and found that OAS3 was dysregulated and highly expressed in almost all TCGA tumour types and was associated with the staging or metastasis of DLBC, HNSC, KIRC, LIHC, LUSC, MESO, OV, PAAD, LUAD, SKCM, and UCS. Here, OAS3 is linked to cancer.