In line with in vitro study, the expression of E-cadherin and Smad7 was dramatically increased and that of Ki-67, N-cadherin and Vimentin was significantly decreased in the xenograft tumor with overexpression of circFGGY, which could be rescued by miR-545-3p agomir (Figures 7E,F and Supplementary Figure S2E). The gene discussed is SMAD7; the disease is neoplasm.