AD P-tau itself cannot bind to microtubules (Alonso et al., 1994), but will bind to endogenous tau and trigger a conformational change, leading to destabilization of the microtubule network (Alonso et al., 1996, 2006, 2010) and disruption of axonal transport (LaPointe et al., 2009; Kanaan et al., 2011). Here, MAPT is linked to Alzheimer disease.