Indeed, CXCL10 is implicated in other sub-states of reactive astrocytes, particularly those driven by interferon signaling in the mouse (Hasel et al., 2021) and visualized in human AD (Xia et al., 2000) and MS (Sørensen et al., 1999) post-mortem samples. Here, CXCL10 is linked to Alzheimer disease.