Pathway enrichment analyses showed that the following pathways were significantly enriched among the genes upregulated in macrophages infected with UK1 (P < 0.05): cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway, influenza A, AGE-RAGE signaling pathway in diabetic complications, herpes simplex infection, Salmonella infection, cytosolic DNA-sensing pathway, apoptosis, RIG-I-like receptor signaling pathway, GnRH signaling pathway, necroptosis, MAPK signaling pathway and ErbB signaling pathway (P <0.05) (Supplementary Table 2). This evidence concerns the gene GNRH1 and herpes simplex infectious disease.