MAP3K8 and inflammatory bowel disease: The IBD risk allele decreased the acetylation at H3K27 and downregulated the expression of MAP3K8. Five of the colocalizing variants overlapped this actQTL peak, of which only one SNP, chr10:30,434,664 (rs306588), overlapped a 1.5 kb ATAC peak (chr10:30,433,210–30,434,733; Tables S3 and S7).