However, we postulate that a very characteristic disease, i.e., craniofrontonasal dysplasia (CFND) resulting from pathogenic variants of the EFNB1, should be considered a standalone genetic disorder in which features other than CS guide the proper diagnosis (Bukowska-Olech et al., 2021). This evidence concerns the gene EFNB1 and Craniofrontonasal dysplasia.