MTOR and pachyonychia congenita: The 5′ adenosine monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) pathways contribute to PC carcinogenesis and its malignant progression by enhancing survival, invasiveness, angiogenesis, proliferative growth, EMT, chemo- and radio-sensitivity, autophagy, stemness, and immune evasiveness of PC cells [135–140].