The genetic, epigenetic, transcriptional, translational, and post-translational loss of function of the tumor-suppressor p53 pathway may induce diverse cancerous cellular phenotypes of PC cells such as oncogenesis, metastasis, invasion, migration, EMT, proliferation, cell adaptation, and plasticity, and its functional restoration and activation not only inhibit the aforementioned pro-tumorigenic cellular processes but also induce antitumorigenic senescence and cell cycle and growth arrest of PC cells [119, 168–172]. This evidence concerns the gene TP53 and pachyonychia congenita.