Luteolin induces apoptosis and chemosensitization but suppresses EMT, invasiveness, and angiogenesis of PC cells by targeting EGFR, Ras, GSK3-beta, IL-6, NF-κB, STAT3, DPYD, VEGF, MMP, MMP, caspase, Bcl-2, PARP, and mitochondrial pathways [193–198]. Here, STAT3 is linked to pachyonychia congenita.