NFKB1 and pachyonychia congenita: Dysregulation of the nuclear factor kappa B (NF-κB) pathway is associated with reduced survival of patients with PC, and it has been considered as a promising target to suppress carcinogenicity, angiogenesis, malignant inflammation, metastasis, growth and proliferation, stem cell-like characteristics, and therapeutic resistance phenotypes of PC cells [165–167].