The Janus kinase (JAK)/STAT pathway is involved in carcinogenesis, development, growth, metastatic and angiogenic behaviors, immune surveillance, growth, stemness, anoikis resistance, EMT, treatment resistance, and invasion and migration of PC cells, while its activation is related to the reduced survival of patients with PC [115–121, 163, 164]. This evidence concerns the gene SOAT1 and pachyonychia congenita.