MAPK1 and pachyonychia congenita: Kaempferol plays a crucial role in the regulation of the activities of Akt/mTOR, EGFR, ERK, Src, Bcl-2, caspase, PARP, TGM2, and ROS cascades, which leads to the suppression of survival, chemoresistance, and migration abilities of PC cells [189–192].