In human neuroblastoma cells, acute and chronic cocaine treatment decreased the level of miR-125b and increased the expression abundance of PARP-1, but did not change the level of cleaved-PARP-1 (Dash et al., 2017), implied that miR-125b was probably associated with DNA damage repair, and might have little effect on apoptosis marked by cleaved-PPAR-1. The gene discussed is PARP1; the disease is neuroblastoma.