Our results indicated that a panel of E2F target gene signature, comprising of HN1, KIF4A, CDCA3, CDCA8 and SSRP1, is a reliable tool for predicting the overall survival of Hepatocellular carcinoma patients, and provided significant reference of clinical risk for Hepatocellular carcinoma patients. Here, CDCA8 is linked to hepatocellular carcinoma.