Herein, we found that KIF18A was highly expressed in glioma, and then we constructed gene-gene interactions and protein-protein interaction networks to identify the molecules most related to KIF18A, including RRP7A, ANAPC4, WEE1, CDC20, and NDC80, and we found that most of them were associated with the cell cycle and cell division. This evidence concerns the gene CDC20 and central nervous system cancer.