Herein, we found that KIF18A was highly expressed in glioma, and then we constructed gene-gene interactions and protein-protein interaction networks to identify the molecules most related to KIF18A, including RRP7A, ANAPC4, WEE1, CDC20, and NDC80, and we found that most of them were associated with the cell cycle and cell division. Here, KIF18A is linked to central nervous system cancer.