The slc12a3 mRNA expression levels are found to be over-expressed in kidneys of db/db mice from 6, 12, and 26 weeks at the age compared with the control mice at the same ages, suggesting that SLC12A3 may play an important role not only in the kidney cloacal development but also in progress of DKD (Abu Seman et al., 2014). The gene discussed is SLC12A3; the disease is diabetic kidney disease.