Furthermore, the single nucleotide variant (SNV) Arg913Gln in the SLC12A3 gene is found to be associated with DKD in type 2 diabetes (T2D) subjects (Tanaka et al., 2003; Nishiyama et al., 2005; Abu Seman et al., 2014; De la Cruz-Cano et al., 2019). This evidence concerns the gene SLC12A3 and type 2 diabetes mellitus.