It was found that male gender, old age (>65 years old), specific complications (hypertension or diabetes mellitus), eGFR < 60 ml/min 1.73 m2 on admission, WBC > 9.5 × 109/L, N% > 6.3 × 109/L, L% < 1.1 × 109/L, PLT < 125 × 109/L, CRP > 10 mg/L, ALB < 35 g/L, PA < 200/L, BUN > 7.5 mmol/L and Cr > 73 μmol/L, as well as the chest CT that demonstrated that the pulmonary lesions involved the whole lobe or segment of the lung, and the clinical subtype of critically ill on admission were significantly associated with a higher mortality rate during hospitalization (P > 0.05, Table 4). The gene discussed is CRP; the disease is Hypertension.