XIII and XVII cells were enriched for enhancers and super-enhancers related to NOTCH signaling and nervous system development genes including, but not limited to, ASCL1 and NEUROD1, which are basic-helix–loop–helix (bHLH) transcription factors with known functions in neuronal cell fate and differentiation of glioblastoma stem cells (GSCs) as well as normal neuronal cells [53–57]. The gene discussed is ASCL1; the disease is glioblastoma.