By contrast, XIII-WT and XVII-WT cells were enriched for a number of FOS::JUN family transcription factors motifs, which have previously been identified to either be enriched in wild-type H3K27 high-grade gliomas or shared across multiple glioma subtypes (Fig. 4b and Additional file 1: Fig. S3b) [23]. This evidence concerns the gene JUN and glioma.