ASCL1 and diffuse intrinsic pontine glioma: Our group and others have shown that ASCL1, in connection to NOTCH and WNT signaling pathways, likely plays a key role in GBM and DIPG tumors and can act as a pioneer factor to bind to chromatin to promote a more open chromatin configuration at enhancers of neuronal genes [19, 30, 55, 56, 58].