Afterwards, expression of NRGs between CRC and normal samples was compared, revealing that genes with CNV amplification were significantly enriched in tumor samples compared to the normal, such as MYC, FADD, AURKA, TRAF2 and PGAM5, while the expression of TLR3, CHUK, RIPK1, FAS, NFKB1 and AXL was markedly decreased in tumor samples, consistent with that of CNV deletion (Fig. 1G). The gene discussed is PGAM5; the disease is colorectal carcinoma.