TGFB1 and colorectal carcinoma: Therefore, we postulated that there were two stable TME patterns mediated by necroptosis in CRC: a phenotype characterized by few TME cells infiltration but with EMT/TGF-β pathways activation, and another phenotype characterized by remarkable stromal cells infiltration, together with EMT, TGF-β signaling pathway activation, corresponding to the immune-excluded and CMS4-like phenotype.