Pharmacological inhibition of METTL3 in vivo can weaken the proliferation of AML stem cells or leukemia, inhibit the expansion of AML, and lead to transplantation damage and prolongation of survival time of AML mice, but there was no such expression in normal non-leukemic hematopoietic cells [114]. The gene discussed is METTL3; the disease is acute myeloid leukemia.