PACS1 and Behcet disease: We then further analysed whether rs3862386 regulates the expression of PACS1 and YIF1A. Deletion of the genomic sequence (331 bp) containing rs3862386 (Fig. 5h; Additional file 1, Figure S3) led to dysregulation of PACS1 and YIF1A (Fig. 5i, j), indicating the regulatory effect of rs3862386 on PACS1 and YIF1A. These data suggested that rs3862386 may confer risk for BD by modulating PACS1 and YIF1A expression.