YBEY and breast carcinoma: Shidal et al. [88] showed that the functional variants rs35418111 and rs2078203 (in LD with the index variant in the 21q22.3 risk locus) might be involved in the occurrence of breast cancer by regulating the expression of YBEY. In addition to these reports, other studies also have revealed that several functional variants in a specific risk locus contributed to disease susceptibility by modulating the same risk gene [89, 90].