Mechanistically, WDR4 promotes the transcription of Cyclin B1 (CCNB1) by facilitating the binding of eukaryotic translation initiation factor 2A (EIF2A) to CCNB1 mRNA transcripts, while WDR4 itself is also regulated by MYC. Taken together, m7G regulators serve an indispensable function in the development of HCC, which may provide potential targets for future treatment. The gene discussed is WDR4; the disease is hepatocellular carcinoma.