For example, METTL1 and WDR4 play a strong carcinogenic role in AML, BC, ESCC, glioma, HCC, HNSCC, ICC, LC, and NPC, promoting the malignant phenotype and progression of tumors [24, 26, 43, 52, 56, 59, 60, 66, 68, 78]; however, METTL1 exerts a significant anti-cancer effect in CC [48]. The gene discussed is WDR4; the disease is esophageal squamous cell carcinoma.