METTL1 is related to the sensitivity of chemotherapy in various cancers: overexpression of METTL1 increases the sensitivity of CC to cisplatin, while stable knockdown of METTL1 can relieve resistance to cisplatin and docetaxel in NPC and 5-fluorouracil in cervical cancer [78, 83]. Here, METTL1 is linked to nasopharyngeal carcinoma.