Based on these observations, we treated THP1-derived macrophages with OxLDL to mimic hypercholesterolemia, and then investigated whether SORBS2 could regulate inflammatory process and the formation of macrophage-derived foam cells, and thus contribute to the progression of atherosclerosis (AS) in hypercholesterolemic populations. The gene discussed is SORBS2; the disease is familial hypercholesterolemia.