In another preparation, TRAIL/S‐layer/graphene GD nanohybrid is used to enhance stability of tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) as a main apoptosis-inducing factor and was cytotoxic (80% apoptosis) on intrinsically-TRAIL resistant HT-29 colon cancer cells [137]. This evidence concerns the gene TNFSF10 and malignant colon neoplasm.