For example, hispidulin inhibited HCC cell proliferation and metastasis by activating of peroxisome proliferator-activated receptor γ (PPARγ ) [13] and another study demonstrated that hispidulin suppressed allergic inflammatory reaction by reducing histamine release and inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4 ) [14]. This evidence concerns the gene IL4 and hepatocellular carcinoma.