Meanwhile, the levels of D-dimer [961.50 (294.50, 3360.25) ng/mL vs. 263.00 (138.00, 604.00) ng/mL, p < 0.001], FIB [4.30 (3.59, 4.95) g/L vs. 3.37 (2.83, 4.18) g/L, p < 0.001], FDP [5.40 (2.31, 10.61) μg/mL vs. 2.39 (1.07, 4.43) μg/mL, p < 0.001)], LDH [197.00 (171.75, 226.50) U/L vs. 170.00 (148.00, 191.75) U/L, p < 0.001] and HBDH [142.50 (128.00, 159.25) U/L vs. 123.50 (109.00, 136.75) U/L, p < 0.001] in patients with RA-ILD were significantly higher than in those with RA-non-ILD (Fig. 2). This evidence concerns the gene OTOR and interstitial lung disease.