The levels of CEA [2.30 (1.21, 3.81) ng/mL vs. 1.39 (0.95, 2.03) ng/mL, p = 0.001], CA19-9 [9.14 (5.59, 22.44) KU/L vs. 5.04 (3.12, 8.01) KU/L, p < 0.001] and CA242 [6.89 (4.01, 13.14) KU/L vs. 3.85 (2.86, 6.01) KU/L, p < 0.001] were higher in patients with RA-ILD than RA-non-ILD, but no significant between-group difference was noted for NSE, SCC, AFP, CA125, and CA153 (all p > 0.05). Here, AFP is linked to interstitial lung disease.