The aim of this systematic review is to gain an understanding of the genetic underpinnings linking intellectual disability (ID) and social behavior in the context of three critical risk factor genes DCX, COMT, and FMR1. In the study by Kwan et al. [1] the authors used a method similar to ours which involved identifying signaling pathways associated with Autism Spectrum Disorder (ASD) and ID based on risk factor genes linked to these disorders that were identified in genomic studies. The gene discussed is COMT; the disease is Intellectual disability.