MAPT and Alzheimer disease: Many AD studies demonstrated that the accumulation of misfolded amyloid \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β and tau protein causes degeneration and loss of neuronal function in the brain [29, 30].