PPARGC1A and cancer: Intriguingly, KDM3A has been reported to demethylate monomethylated lysine (K) 224 of PGC-1α and lead to PGC-1α-dependent mitochondrial biogenesis under normoxic conditions [40], while mitochondrial biogenesis is often upregulated in cancers and plays a central and multi-functional role in malignant tumor progression [41].