TCF4 and psychiatric disorder: Here, we leverage data from the Electronic Medical Records and Genomics (eMERGE) consortium that includes real-world phenome-wide medical data and deep sequencing of the ACMG-56 genes (v1.0; Table S1) [17, 18], as well as two genes previously implicated in major psychiatric traits (CACNA1C and TCF4) [19, 20] to examine whether rare variants in these genes are associated with mental illnesses for 15,181 individuals of European descent.