It is interesting, nonetheless, that among the suggestive burden of rare variants are two channel genes, KCNQ1 and CACNA1S, associated with substance use disorders and depression, respectively (Table 1), which involve in the formation and function of potassium and calcium channels that are broadly implicated in brain-related disorders [19, 37]. The gene discussed is KCNQ1; the disease is depressive symptom measurement.