A few genes causing rare or Mendelian heart conditions were also implicated, such as LDLR (burden of nonsynonymous variants in major depressive disorder: OR = 2.10, p-value = 3.6 × 10–4) and APOB (burden of PTVs in Tobacco use disorder: OR = 12.99, p-value = 1.1 × 10–3), both linked to familial hypercholesterolemia (Table S1). This evidence concerns the gene APOB and familial hypercholesterolemia.