In addition, we also found that miR-6511b-5p can directly target brahma-related gene 1 (BRG1), also known as SMARCA4, a key regulator of CD44 and a major transcriptional regulator [18, 19], to suppress invasion and migration by regulating CD44 in pMMR colorectal cancer cells. This evidence concerns the gene SMARCA4 and colorectal cancer.