The hepatic and renal protective effect of candesartan against Cd-induced hepatorenal intoxication was determined by assessing hepatic function biomarkers; SGPT, SGOT, and ALKP, and renal function biomarkers; albumin, creatinine, urea, uric acid, KIM-1, and NGAL (Table 3). This evidence concerns the gene LCN2 and intoxication.