For comparison to NEC, immunohistochemical expression of RB, p53, and p16 was also assessed in the group of grade 3 NET (n = 8), as well as in two grade 3 IDC-NED and one grade 3 ILC-NED (Fig. 3 and Supplementary Tables S3 and S8). This evidence concerns the gene RB1 and neuroendocrine carcinoma.