Marchiò et al. reported recurrent alterations in GATA3, FOXA1, TBX3, ARID1A, PIK3CA, AKT1, and CDH1 in a series of IDC-NED, mucinous, and solid papillary carcinomas, which included only three grade 3 cancers; FOXA1, CDH1, AKT1, and KMT2C alterations were seen in one of the latter65. This evidence concerns the gene PIK3CA and cancer.