CLCN7 and osteopetrosis: We collected BMDMs from Tmem206−/− mouse lines (Extended Data Fig. 4a–d), which lacked obvious pathology, and from Cx3cr1-CreERT2; Clcn7lox/lox mice in which Clcn7 was disrupted in the monocyte lineage22 to avoid the osteopetrosis and early death of Clcn7−/− mice20.