We did not detect any significant associations between T-ALL methylation-based groups and genetic subtypes, age, sex or recurrent mutations (Fisher’s exact test, P values >0.05 in Supplementary Tables 10 and 11 and Fig. 5a), although samples with the HOXA or TLX3 subtype seemed to more frequently co-occur with T-ALLIM and T-ALLHM groups in line with previous findings31. The gene discussed is TLX3; the disease is acute lymphoblastic leukemia.