Following report revealed another two TINF2 truncating mutations, p.Glu202fs/p.Leu170fs and p.Ser186fs, in altogether four cancer-prone families, where six TINF2 mutation carriers developed numerous malignancies, including three papillary thyroid carcinomas, two melanomas and three breast carcinomas. This evidence concerns the gene TINF2 and differentiated thyroid carcinoma.