However, HCT is not recommended in CR1 in the favourable risk group, including AML patients with core-binding factor (CBF) that are associated with translocations t(8;21), inv(16) or t(16;16) and NPM1 mutation plus wild-type FLT3-ITD or FLT3 with low-allele ratio (<0.5) (although this may be controversial) [1, 14]. The gene discussed is NPM1; the disease is acute myeloid leukemia.