CD8A and Splenomegaly: CD8 T cell activation was previously noted in CVID as Viallard et al. observed an inverse relation between naïve and activated CD8 T cells in CVID [22], Lanio et al. saw higher proportion of activated CD8 T cells in patients with splenomegaly [21], Carter et al. noted elevated proportion of HLA-DR+ cells but no association with autoimmune phenomena [19], and de Lollo noted higher proportion of CD127−38+ cells in patients with splenomegaly compared to healthy donors [20].