Comparing the results from the recent GWAS studying over 1 million individuals23 and the previous results by the same group (base GWAS), using largely data on the same samples it is interesting to note that 8 loci that were significant in the base GWAS have not been found to be associated with AD in the larger, more recent study: ADAMTS4, HESX1, HS3ST1, CNTNAP2, KAT8, SUZ12P1 (DSG2), ALPK2 and AC074212.3. This evidence concerns the gene ALPK2 and Alzheimer disease.