By performing integrated data analysis of Pcbp1-knockdown RNA-seq and PCBP1 CLIP-seq, our study suggests that PCBP1 probably participates in the molecular mechanism of RA via not only affecting the expression of genes involved in immune and inflammatory response in Th1 cells, but also binding to and regulating the alternative splicing of immune response related genes in Th1 cells. This evidence concerns the gene PCBP1 and rheumatoid arthritis.