SRSF1 and malignant colon neoplasm: As well as showing increased expression of differentiation marker genes, Srsf1 reduction resulted in a decrease in the stem cell marker Prox1. PROX1 is a Wnt-regulated transcription factor that has been shown to advance colon cancer progression by promoting dysplasia in colonic adenomas54, as well as enhancing metastasis in Wnt-driven progenitor cells44.