In addition to the critical contributions from immune system cells, we have recently shown that NF1 mutation in neurons synergizes with light-induced retinal ganglion cell activity to regulate neuroligin-3 (NLGN3) shedding and Nf1-optic pathway glioma (Nf1-OPG) initiation and growth22. The gene discussed is NLGN3; the disease is optic pathway glioma.