PRRX1 and cancer: PRRX1 was more highly expressed in CAFs than in fibroblasts of normal tissues, and PRRX1 expression was strongly correlated with fibroblast-activation score in all six datasets from six organs, including cancer and normal tissues (lung, colon, pancreas, head and neck, ovary, and stomach) (Fig. 1A, B, Supplementary Fig. 1B).