TP53 and cancer: Broadly speaking, cancer-associated p53 missense mutant proteins can be divided into two main classes: (A) structural mutants, where the mutation causes misfolding of the protein and leads to a significant conformational alterations within p53’s DNA binding domain (DBD), and (B) DNA contact mutants, where the overall structure of the DBD is only minimally perturbed, but the mutant protein loses its ability to engage in high-affinity sequence-specific interactions with p53 binding sites within the DNA11,12.