At 35 weeks, IHC analysis showed AR+ prostate tumors in all mice, but expressions of Ki67+, c-MYC, p-IKKα/β, and p-p65 were lower in Tubb4a-cKO TRAMP versus WT TRAMP prostate tumors (Fig. 9H, I). The gene discussed is CHUK; the disease is prostate neoplasm.