Of note, IHC analysis showed lower expressions of cyclin D1, c-MYC, p-IKKα/β, p-p65, and vimentin but higher expression of E-cadherin in TUBB4A KO metastatic tumors compared to scrambled metastatic tumors (Figs. 7F and S9B). The gene discussed is CCND1; the disease is metastatic neoplasm.