In DU145 cells, TUBB4A KO or MYH9 KD increased the expression of GSK3β but decreased the expression of nuclear β-catenin and its downstream targets, cyclin D1 and c-MYC (Fig. 5E), suggesting TUBB4A/MYH9-mediated GSK3β/β-catenin signaling in human cancer cells (Fig. S7E). The gene discussed is MYC; the disease is cancer.