As shown in Fig. 9A–E, the onset of prostate tumor and mouse death were delayed in homozygous Tubb4a-cKO (also Tubb4a-cKO) TRAMP mice compared to heterozygous Tubb4a-cKO or Tubb4a wild-type (WT) TRAMP mice. The gene discussed is TUBB4A; the disease is prostate neoplasm.