Our IHC analysis showed a reduced expression of CK5 in the Tubb4a/Pten-cKO versus Pten-cKO mPIN lesions (Fig. S12B) but no change between Tubb4a-cKO TRAMP and WT TRAMP prostate tumors (Fig. S12C). The gene discussed is PTEN; the disease is prostate neoplasm.