At 35 weeks, IHC analysis showed AR+ prostate tumors in all mice, but expressions of Ki67+, c-MYC, p-IKKα/β, and p-p65 were lower in Tubb4a-cKO TRAMP versus WT TRAMP prostate tumors (Fig. 9H, I). This evidence concerns the gene MKI67 and prostate neoplasm.