NOTCH1 and acute lymphoblastic leukemia: As expected, IACS-010759 inhibited OxPhos across T-ALL cell lines (n = 11), reducing basal and maximal OCR in both NOTCH1-wt and -mutant cell lines (p = 0.05 and p = 0.005, respectively, Supplementary Figs. 3c–d, 4), with the latter showing greater sensitivity to OCR inhibition when compared to T-lymphocytes (p = 0.0006, Fig. 2i, Supplementary Fig. 3e).