NOTCH1 and cancer: In addition, OxPhos genes were significantly over-represented among T-ALL dependent genes, as compared to those for hematologic malignancies or other cancer cell lines (p = 0.03 and p = 0.048, respectively; Supplementary Fig. 1g) suggesting the importance of OxPhos genes for T-ALL survival38.Taken together, bioinformatic analysis provides evidence that oncogenic activation of NOTCH1 is associated with OxPhos, and suggested that treatment with OxPhos-i could reduce the viability of murine and human T-ALL, potentially depending on NOTCH1 status.