NOTCH1 and acute lymphoblastic leukemia: In all three NOTCH1-mutated T-ALL PDX models, OxPhos-i/VXL produced a profound reduction of spleen size (Supplementary Fig. 33b), spleen weight (p < 0.0001; Supplementary Fig. 33c), and tumor burden reduction in PB (Supplementary Fig. 33d), spleen (Fig. 6e; Supplementary Fig. 33f), and BM (Supplementary Fig. 33e, f).