NOTCH1 and acute lymphoblastic leukemia: At the molecular level, T-ALL is associated with abnormalities in oncogenic transcription factors5,6, with the most frequent activating mutations in NOTCH1 that lead to upregulation of the pro-survival NOTCH1 signaling7–9 and mutations in FBXW7 gene, which is similar to mutations in NOTCH1 PEST domain, results in increased ICN1 protein stability, often co-occurring with mutations in NOTCH110–12.