Oxygen consumption rate (OCR) measurements in T-lymphocytes and T-ALL cell lines separated by NOTCH1 mutation status showed an increased OCR in a subset of cells with NOTCH1 wild type (wt) (p = 0.03; Fig. 2h) and in all cell lines harboring NOTCH1 mutation (p = 0.0004; Fig. 2h) compared with OCR of healthy T-lymphocytes. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.