Bioinformatic analysis of various datasets from T-ALL12,33, normal thymocytes34, and murine T- ALL cell lines35 indicated that NOTCH1-bound target genes (NBTs) were enriched for MYC targets, genes of the OxPhos pathway, the tricarboxylic acid (TCA) cycle, and the mitochondrial electron transport chain (ETC) (Fig. 1a)35,36, possibly linking NOTCH1 signaling to MYC and OxPhos. This evidence concerns the gene MYC and acute lymphoblastic leukemia.