NOTCH1 and acute lymphoblastic leukemia: To define the metabolic effects of OxPhos-i in NOTCH1-mutated T-ALL cells, we performed an untargeted metabolomics analysis that showed accumulation of nucleoside monophosphate (NMP) (p = 0.04) and redox imbalance, as indicated by diminished ratios (reductive to oxidized) of glutathione and coenzyme Q10 (CoQ10) (Supplementary Fig. 9a).