Consistent with this, IACS-010759 produced striking dose-dependent inhibition of ATP production in T-ALL lines (Supplementary Fig. 3f), with the lowest IC50 in NOTCH1-mutant lines versus T-lymphocytes (p = 0.0006, Fig. 2j), while only moderate ATP and viability reduction of less than 20% at the highest dose was seen in healthy T-lymphocytes (Supplementary Fig. 3f–h). This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.