NOTCH1 and acute lymphoblastic leukemia: As compared to samples without NOTCH1 mutation, there was a higher activity of OxPhos signature genes in NOTCH1-mutant T-ALL (p = 0.012) along with several pathways associated with mitochondrial machinery (p = 0.01; Fig. 1d–f, Supplementary Fig. 1c–e) and a lower activity of apoptosis pathways (p = 0.0073; Fig. 1d, g; Supplementary Fig. 1c, f).