MAP3K14 and Glucose intolerance: While, transgenic overexpression of NIK specifically in β-cells (β-NIK-OE mice) resulted in early spontaneous diabetes onset in mice due to insulitis and β-cell death, mice expressing NIK constitutively in β-cells due to TRAF2/3 depletion showed no diabetic phenotype up to 16 weeks of age with a mild glucose intolerance under control chow diet [13, 14].