The low doses of STZ are specifically toxic to β-cells generating localized inflammation which is comparable to the inflammatory process described in human pancreas during T1D and the autoimmune nonobese diabetic (NOD) mouse model, namely, insulitis with initial attraction of neutrophils and macrophages followed by T cells, which causes progressive decrease in insulin levels due to β-cell destruction [21–24]. Here, INS is linked to type 1 diabetes mellitus.