RNPC3 and neurodegenerative disease: In neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS) or Frontotemporal Degeneration (FTD), in contrast, accumulation of static RNP aggregates with aberrant composition has been reported, suggesting that such pathological aggregates might trap RNA binding proteins (RBPs) and be involved in disease progression41–43.